New Health Affairs Issue Focuses On Health Care Reform, USA

Despite the prominent role that health care reform is playing in the 2008 presidential election, leading Republican and Democratic pollsters agree that deep partisan divides among voters — combined with a worsening economy — may permit only incremental, rather than sweeping, changes to the health care system. The perspectives of political pollsters William McInturff and Celinda Lake are featured in a far-reaching thematic issue on health reform in the May/June 2008 issue of the journal Health Affairs.

The journal will be highlighted at a May 13 briefing that will include presentations from health advisers for the three presidential candidates. The issue and briefing are supported by a grant from the Robert Wood Johnson Foundation.

Republican pollster McInturff and colleague Lori Weigel analyze data from multiple national public opinion surveys to show how lingering perceptual barriers that doomed previous major reform efforts may do the same this round. Those barriers include an unwillingness on the part of the American public to accept certain trade-offs in return for universal coverage, as well the desire to fix other problems in the health care system before overhauling it entirely, they write.

Nevertheless, the pollsters identify two factors that could differentiate this effort from the last major health reform push during the Clinton administration. First, small-business owners hit by rising premiums are calling for major reform. Second, people see health care reform as an essential and affordable priority for government spending in the wake of ballooning costs of the military efforts overseas. “Health care will continue to be on the agenda no matter who wins in November. How much the next president addresses and overcomes the persisting barriers from the last health care debate will likely determine the fate of reform these fifteen years hence,” McInturff and Weigel conclude.

Democratic pollsters Celinda Lake, Robert Crittenden, and David Mermin present key opportunities and drawbacks for health care reform. Although the 2008 election could “set the stage for the most significant reform of the U.S. health care system since Medicare,” Lake and colleagues warn that the political system is slow to act and that a well-funded opposition will work hard to prevent major change. “The next president will have to campaign actively and vocally on health care reform and move quickly in his or her first year in office to be successful,” they write. What is unique this year, they add, is that “the core ideas and rhetoric embedded in the leading health care proposals are more in tune with the experience and values of voters than they have been in previous reform battles.”

Separately, a series of papers in the issue examines the failure of the Clinton reforms in the 1990s and looks at lessons learned for the future. In separate pieces, authors Joseph Antos; Christine Ferguson, Elizabeth Fowler, and Len Nichols; and Jacob Hacker look at the politics and policy of the Clinton plan’s demise.

Sens. Ron Wyden (D-Ore.) and Bob Bennett (R-Utah) also write in the journal that their Healthy Americans Act reflects what they see as important bipartisan movement to seek consensus on an approach to reform. They join a host of other health care experts from various sectors of the health care industry who offer various positions on the role of taxes, the federal budget, and other building blocks that could improve access, temper costs, and improve quality.

Other highlights in this issue:

Taxes And Budgets. Achieving almost any new major federal budget priority will be nearly impossible if health costs continue to soar, write Eugene Steuerle and Randall Bovbjerg of the Urban Institute. If current trends persist, sometime between 2016 and 2020 existing federal revenues will cover only health entitlements, Social Security, debt service, and a smaller defense budget, leaving nothing for anything else, including the environment, education, or new health initiatives. The researchers warn that budget-driven reforms in health policy must aim to end automatic year-to-year budget growth and push Congress to formally recognize when it chooses health cost increases over other priorities. Steuerle and Bovbjerg warn policymakers against getting derailed by the search for one grand reform; instead, they suggest a host of reforms that would empower government, providers, insurers, and citizens alike to choose a better and more efficient health care delivery system, and one with much better coverage to boot.

Jason Furman, a senior fellow at the Brookings Institution, analyzes a range of proposals to change health care through tax reforms. He suggests that the best option would be replacing the current tax preference for employer-sponsored insurance with an income-related, refundable tax credit. Although this approach by itself would involve considerable risks, Furman says that it has the potential to increase coverage and reduce inefficient health spending at no net federal cost. “Current tax expenditures for health care provide a pool of $200 billion that could be used to finance expanded or even universal coverage, with additional resources potentially left over for debt reduction or tax cuts,” he writes.

Formulas For Compromise. A compromise model of health care reform that draws on past reform experiences may expand coverage and focus spending on high-value care, explains Katherine Baicker, a professor of health economics at the Harvard School of Public Health. Financial strains on both public and private budgets — such as Medicare’s current financial woes, the possibility of tax reform, and pressure on private stakeholders — might foster such a compromise. “Reforms should aim not just to expand insurance coverage today but also to put in place a system that would allocate health resources more efficiently so that we would be able to afford the coverage tomorrow,” Baicker writes.

Karen Davis, Cathy Schoen, and Sara Collins of The Commonwealth Fund offer a method to provide universal coverage with minimal net increases in national health spending. Their “Building Blocks” approach includes a Medicare-like option for people under age 65, along with a choice of private plans offered to small businesses, the self-employed, and everyone without large-employer insurance or Medicare. Other features include an individual mandate, required employer contributions, Medicaid/State Children’s Health Insurance Program (SCHIP) expansion, and tax credits to assure affordability.

In the event that the new president should put forward a universal coverage proposal, the CEO of Blue Shield of California, Bruce G. Bodaken, writes that the president’s ability to attract support from the insurance industry will be successful if he or she keeps the following criteria in mind: respect the industry’s economics, understand the competitive dynamic, think through the transition, rely on the expertise of the insurance industry, demand shared responsibility, and stop portraying health plans as the adversary.

Improving Quality And Accountability. In addition to expanding coverage, other authors say that a new system must address quality and cost. Margaret O’Kane, president of the National Committee for Quality Assurance; Janet Corrigan, president and CEO of the National Quality Forum; and a distinguished panel of colleagues identify five fundamental steps for the public and private sectors to take to move toward a high-performance health system. The authors’ recommendations includes creating a national center to support effectiveness research; promoting coordinated care; rewarding high-value care; creating a national system for measuring performance; and developing a strategy for improving population health.

The Role Of States. Henry Aaron of the Brookings Institution and Stuart Butler of the Heritage Foundation advocate the importance of giving states more leeway to enact their own reform solutions to lay the foundation for national action. The role of the federal government would be to define adequate coverage for residents, ensure that state plans are sufficient to meet the objective, and design the process for approval of such plans.

Alan Weil, executive director of the National Academy for State Health Policy, argues that state-based health reform should occur in the context of a national strategy. He says that congressional proposals to encourage state action cover too narrow a span of state health policy, do not provide states with sufficient authority to tackle major health policy challenges, and supply insufficient funding.

Health Affairs, published by Project HOPE, is the leading journal of health policy. The peer-reviewed journal appears bimonthly in print with additional online-only papers published weekly as Health Affairs Web Exclusives at www.healthaffairs. Continue reading

Stop Skin Cancer On The Spot: New Tools Aid In Diagnosing And Detecting Skin Cancer In Earliest Stages

Based on current estimates, 8,420 people are expected to die from melanoma this year. In an effort to reverse this sobering trend, dermatologists and the scientific community alike are continually developing new diagnostics, refining detection guidelines and providing patients with the tools they need to properly examine their own skin for signs of skin cancer.

Speaking today at the American Academy of Dermatology’s SKIN academy (Academy), dermatologist Ellen S. Marmur, MD, FAAD, chief of the division of dermatologic and cosmetic surgery at The Mount Sinai Medical Center in New York, presented the latest advances in diagnosing skin cancer and the Academy’s new detection strategies that emphasize the importance of patient involvement.

“There are some exciting innovations in diagnosing skin cancer that can help us detect skin cancer early, when it is most treatable,” said Dr. Marmur. “Even simple detection tools designed by the Academy that patients can use in their own homes can save thousands of lives.”

New Technologies for Diagnosing Skin Cancer

Dermatologists traditionally diagnose skin cancer by evaluating the skin using a clinical examination and, if necessary, a magnifying device and then biopsying any suspicious lesions. Now, technological advances in computers, lasers and other polarizing light sources are providing dermatologists with tools to enhance the evaluation of suspicious lesions and, in some cases, decreasing the number of biopsies needed for an accurate diagnosis. The idea is to hone in on suspicious lesions earlier and with more specificity.

One of the newest technological developments in the fight against skin cancer is the use of sophisticated imaging to scan and enhance certain features of suspected lesions. Similar to how a computerized tomography (CT) scan highlights areas of the brain for abnormalities, imaging devices can now work on the skin to help detect cancerous tissue.

Another exciting technology dermatologists are using to evaluate suspected skin cancers is a hand-held light device known as dermascopy that can look at the pigment of the skin through specialized filters that magnify and polarize lesions. For example, similar to how filters are used on cameras to create certain backgrounds, filters are used on this device to enhance certain features of lesions such as brown or red background colors that could indicate a melanoma (the deadliest form of skin cancer).

Dr. Marmur noted that one of the main benefits of dermascopy is the ability to immediately evaluate a potential melanoma based on its magnified characteristics, which could help decrease the number of biopsies needed to make an accurate diagnosis, or can push the physician to biopsy a borderline lesion that appears more suspicious with the assistance of the dermatoscope.

In addition, newer computer systems are being used in conjunction with hand-held photography devices to more accurately diagnose melanomas. For example, the photo device takes a digital picture of the suspicious lesion, which is then magnified on the computer screen for closer examination. The computer system also contains a database of characteristics of approximately 100,000 evolving melanomas, which the lesions are then graded against to see if certain features score high enough on the scale to warrant having a biopsy.

“With the improvement of early detection methods, we are finding an increasing number of smaller skin cancers,” said Dr. Marmur. “We know from experience that detecting skin cancer in its earliest stage means better cure rates and survival rates. Prognosis plummets as the depth of melanoma increases even by the smallest increment of one millimeter.”

New Self-Exam Tools

Since skin cancer is the only cancer you can see on the surface of your skin at its earliest stage, performing regular skin self-examinations is an easy way to detect any suspicious spots that could be cancerous. To enhance a patient’s ability to detect the warning signs of skin cancer, the Academy is refining the ABCDs of melanoma detection by adding an “E.” The letter “E” stands for Evolving a mole or skin lesion that looks different from the rest or is changing in size, shape or color. This is in addition to other qualities of moles for which individuals should check their skin Asymmetry (one half unlike the other half), Border (irregular, scalloped or poorly defined), Color (varies from one area to another; shades of tan and brown, black; sometimes white, red or blue), and Diameter (the size of a pencil eraser or larger). If a mole exhibits any of these characteristics, it should be brought to a dermatologist’s attention.

An analysis of 2001-2005 data from the Academy’s National Melanoma/Skin Cancer Screening Program supports the need for people to watch their moles for changes. A study of the data published in the July 2007 issue of the Journal of the American Academy of Dermatology found those who indicated they had a mole that changed recently in size, color or shape were two times more likely to be diagnosed with a suspected melanoma.

“Some melanomas don’t show any other abnormalities except that they are evolving over time,” said Dr. Marmur. “It’s not unusual for people to wait until a melanoma has grown significantly to see a dermatologist, and unfortunately, that sometimes means the cancer has spread to other areas of the body. I am confident lives will be saved by encouraging people to bring their evolving moles to the attention of a dermatologist. And I have been able to save lives purely because a partner or spouse has detected a changing lesion on someone who rushed in for a biopsy and curative surgery.”

Dr. Marmur explained she sees numerous patients who say that they have had a mole forever, but that it recently started bleeding and then ultimately turns out to be a skin cancer. She added that a classic example of an evolving skin cancer is a man who notices a mole that begins bleeding while he is shaving. This can be a basal cell carcinoma, a squamous cell carcinoma or a melanoma. All three are serious and can be cured if caught early.

“Melanoma can be on the skin for a long time before it ‘misbehaves’ and gives patients a clue that it may be a lesion that needs to be addressed,” said Dr. Marmur. “We find that people who check their skin regularly looking for the warning signs of skin cancer and taking note of any changes are more likely to spot skin cancer in its earliest stages before it spreads.”

The Academy’s Body Mole Map is a tool individuals can use to track their moles. The map provides information on how to perform a skin exam, images of the ABCDEs of melanoma and space for people to track their moles to determine any changes over time. Free downloads of the Body Mole Map are available at melanomamonday.

Dr. Marmur also encourages her patients to involve a family member or partner in skin exams, which can help people thoroughly examine their skin in hard-to-reach spots and help them decide if a lesion seems to be evolving over time. In her practice, Dr. Marmur estimates that patients report that they are getting a suspicious mole checked at the urging of another person about five times per week with men representing the largest group of referrals.

“My favorite example is of a daughter who had been trying to get her mother to come in to get a suspicious mole on her back checked, but the mother was very reluctant because she didn’t like going to the doctor,” said Dr. Marmur. “Before the daughter went off to college, she asked her mom to make her an appointment at my office to get a spot on her face checked that she was concerned about. When they arrived at my office, the daughter told her mother that the appointment was really for her. The mole turned out to be a melanoma, and we were able to save the mother’s life due to her daughter’s plan to get her to my office.”

Dr. Marmur’s patient story supports recent research that shows involving a partner in the self-examination process can improve the early detection of skin cancer. As such, the Academy is encouraging people to “Screen the One You Love.” While candy and flowers are short-term gifts, the gift of a skin examination is a gift of life and health. Popular holidays, such as Valentine’s Day (February 14), Mother’s Day (May 10), Father’s Day (June 21) and Grandparents Day (September 13) are reminders for people to check their loved ones’ skin for suspicious moles using the Academy’s Body Mole Map.

“People sometimes get confused by what to look for on their skin, and that could result in them ignoring any potential red flags that might be starting to crop up,” said Dr. Marmur. “So I always tell people to get to know their skin and if something is bleeding or doesn’t look right, then see a dermatologist. Whether or not you have a partner available to assist you with your skin self-exam, you should make skin self-exams part of your regular health regimen.”

For more information about skin cancer, please visit the SkinCancerNet section of www.skincarephysicians, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 15,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails.

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Primary Care Diabetes: Elsevier Announces New Journal For 2007

Elsevier and Primary Care Diabetes Europe are set to launch Primary Care Diabetes, an influential new diabetes journal in February 2007. Primary Care Diabetes, edited by Professor Guy EHM Rutten (Utrecht, The Netherlands) will be published quarterly and provide a valuable new resource for general practitioners/family doctors, nurses and other diabetes primary-care workers, by publishing original articles and high-quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research, epidemiology and other related areas.

Primary Care Diabetes is the official journal of Primary Care Diabetes Europe. Guy Rutten is joined by Associate Editors Kamlesh Khunti (UK), Neil Munro (UK) and KM Venkat Narayan (USA) and an international Editorial Board. “Primary Care Diabetes will be an important vehicle for the dissemination of high-quality applied research related to diabetes prevention and control in primary care” commented the editors of Primary Care Diabetes. “Our goal is to promote the implementation of evidence-based diabetes for all those working in a primary care setting and at the primary/secondary care interface.”

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Please visit the journal website at primary-care-diabetes/ to view free Preview Issue content. Subscribers will have full access to each issue as well as articles in press on the journal’s website. Primary Care Diabetes will also be accessible through Elsevier’s online database, ScienceDirect, the world’s largest electronic collection of science, technology and medicine full text and bibliographic information.

About Elsevier

Elsevier is a world-leading publisher of scientific, technical and medical information products and services. Working in partnership with the global science and health communities, Elsevier’s 7,000 employees in over 70 offices worldwide publish more than 2,000 journals and 1,900 new books per year, in addition to offering a suite of innovative electronic products, such as ScienceDirect (sciencedirect/), MD Consult (mdconsult/), Scopus (info.scopus/), bibliographic databases, and online reference works.

Elsevier (elsevier/) is a global business headquartered in Amsterdam, The Netherlands and has offices worldwide. Elsevier is part of Reed Elsevier Group plc (reedelsevier/), a world-leading publisher and information provider. Operating in the science and medical, legal, education and business-to-business sectors, Reed Elsevier provides high-quality and flexible information solutions to users, with increasing emphasis on the Internet as a means of delivery. Reed Elsevier’s ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).

About Primary Care Diabetes Europe PCD Europe (pcdeurope/) exists to provide a focal point for primary care clinicians and their patients. Its purpose is to promote high standards of care throughout Europe. Emphasis is placed on incorporating evidence based medicine into daily practice as well as promoting diabetes education and research in primary care.

Contact: Andrew Miller

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Matrix of brain’s visual center illuminated

In our brains, neurons that respond to combinations of colors, edges and positions in space work together to create the images we see. Neuroscientists at MIT’s Picower Center for Learning and Memory show in the July 21 issue of Neuron that previous theoretical attempts to explain the computational tricks the brain performs to detect all the features of images turn out to be largely right–with a twist.

In the visual cortex, nearby neurons detect objects in nearby parts of space, creating an image or map of the visual scene. Within each part of the map, some clusters of neurons detect the vertical edges in a given region of the visual scene and other clusters the horizontal edges. Some clusters detect stimulation of the left eye and others the right eye.

But this property of the brain, where neurons are clustered according to their ability to detect different properties, raises a tricky issue. If the clusters didn’t overlap with each other the correct way, then we may have “blind spots” for certain feature combinations. For example, in certain regions of the visual scene we may be able to detect vertical edges with only the left eye, or horizontal edges with only the right eye.

A Finnish mathematician tackled this problem in 1982, when he came up with mathematical formulas that showed how the clusters could overlap so that each combination of features could be represented by the cortex.

This study by Mriganka Sur, Sherman Fairchild Professor of Neuroscience and head of the Department of Brain and Cognitive Sciences; postdoctoral associate Hongbo Yu; graduate student Brandon J. Farley; and visiting scientist Dezhe Z. Jin tests the predictions of mathematician Teuvo Kohonen. It does so by factoring in a quirky aspect of some species’ cortical map: It’s distorted.

In some brains, a square region of the visual image is represented by a square region of the cortex. But in other species, the visual cortex is distorted, causing a square region in the visual image to be represented by a rectangular region of cortex. The study reported in Neuron shows that the distortion in the mapping of the visual scene onto the cortex has the influence on clustering that Kohonen’s formulas predicted. The shape of the clusters of neurons representing similar orientations and eyes also are distorted in such a way that each feature combination can still be detected in each part of space.

What’s more, the visual cortex’s solution to accommodating several parameters probably holds true for other brain regions. “Since every part of the cortex has neurons that are involved in multiple tasks, there is every reason to think that this is a deep principle of brain organization,” Sur said. Take hearing, for instance. “Hearing, like seeing, has multiple parameters: location of a sound in space, frequency and relative activation of the two ears,” Farley said. “Maybe mapping multiple dimensions this way is a general strategy the brain uses when it faces this problem.”

This work is supported by the National Institutes of Health.

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Findings Offer Insights Into Role Of Breastfeeding In Preventing Infant Death, HIV Infection

In many poor countries, mothers with HIV face a stark choice: to nurse their infants, and risk passing on HIV through their breast milk – or to formula feed, and deprive their infants of much of the natural immunity needed to protect against fatal diseases of early infancy. Now, two studies supported by the National Institutes of Health offer insights into preventing early death and HIV infection among breastfeeding infants of mothers with HIV in these countries.

The studies were published online in the New England Journal of Medicine and will appear in the publication’s print edition on July 10.

One study was supported in large part by NIH, with additional funding by the Centers for Disease Control and Prevention and the United States Agency for International Development. That study found no benefit for infants born to mothers with HIV from abrupt cessation of breastfeeding after the first four months of life. In addition, this study found no difference in HIV infection rates or in death rates by age 2 among infants abruptly weaned off all breast milk at four months versus those who breast fed until later in infancy. In fact, for one group of infants, those infected with HIV, abrupt cessation of breastfeeding resulted in an increased death rate.

The other study, co-sponsored by the NIH and the Centers for Disease Control and Prevention, found that it was possible to greatly reduce the risk of HIV infection in breast-feeding infants by treating them with an extended anti-HIV regimen. The treatment consisted of the anti HIV drug nevirapine, alone or in combination with the drug zidovudine, during the first 14 weeks of life.

“In poor countries where sanitation is a problem, exclusive breastfeeding appears to confer the greatest benefits to infant health and survival, even in mothers with HIV” said Duane Alexander, M.D., director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH institute that provided much of the support for the two studies. “Extended treatment with nevirapine greatly reduces the chances that infants will be infected with HIV through breast milk. The National Institutes of Health is now sponsoring additional studies to determine the most effective treatments to prevent the spread of HIV through breast milk.”

In the developed world, mothers with HIV forego breastfeeding and formula feed their infants, said Lynne Mofenson, M.D., Chief of NICHD’s Pediatric, Adolescent and Maternal AIDS Branch, and the project officer for the two studies. But in many poor countries, there are barriers to formula feeding. Sanitation is lacking, and clean water to mix formula is often not available. Many families have difficulty affording infant formula. They also have difficulty providing enough wood or charcoal for cooking fires to boil water needed for formula.

Formula fed infants also miss out on protective antibodies – passed on through breast milk – needed to ward off the deadly infant diseases prevalent in many parts of the world. Formula feeding, also, may carry a social stigma for mothers. The practice is often seen as a tacit acknowledgement that a woman has HIV.

“Formula feeding is a hardship in many poor countries,” Dr. Mofenson said. “So the finding that it doesn’t confer any apparent benefits in resource poor settings – and may even be harmful – has important implications.”

The first of the two studies was conducted by Louise Kuhn, Mailman School of Public Health, Columbia University, New York, and colleagues from the Boston University School of Public Health, University of Zambia, and other institutions.

The study was conducted in Lusaka, Zambia. The researchers enrolled 958 women with HIV and their infants. The women consented to be randomly assigned to one of two groups. In the first, or intervention, group, 481 women were counseled to exclusively breastfeed their infants for four months, not offering any formula or other liquids. The women were advised to stop all breastfeeding when their infants were four months old. The women were also provided with formula and instructed in how to safely prepare it. In the second, or control, group, the women were advised to continue breastfeeding for as long as they chose to. Infants were tested for HIV at birth, and then periodically throughout the study, until they were 24 months of age.

In the intervention group, 69 percent of infants had stopped breastfeeding by 5 months of age. Children in the control group stopped breastfeeding at a range of ages, between 5 and 24 months of age. Only 7 percent of children in the control group had stopped breastfeeding by 5 months of age and 66 percent were still breastfeeding at 12 months of age.

The researchers found no significant differences in survival between the two groups. In the intervention group, 76.1 percent had survived to 24 months of age, versus 75.4 percent in the control group. Among infants who were still breastfeeding and uninfected at 4 months, there was also no significant difference in HIV-free survival by 24 months (83.9 percent in the intervention group, versus 80.7 percent in the control group.)

Breastfeeding appeared to improve survival among infants who were infected with HIV. Children in the intervention group who were infected with HIV at or before 4 months of age and still alive at 4 months of age had higher death rates by 24 months than did their counterparts in the control group (73.6 percent versus 54.8 percent). Causes of death were predominantly diarrheal and respiratory diseases, but also included malaria, malnutrition, measles, and injury.

The researchers were surprised to find that the proportion of new HIV infections between 4 and 24 months were not significantly different between the two groups despite differences in the time breastfeeding was stopped: 6.2 percent in the intervention group and 8.8 percent in controls. The researchers theorized that the chances of transmitting the virus may increase as a result of the weaning process. The breast swelling and infection (mastitis) that occurs when breastfeeding is sharply reduced may increase the likelihood that the virus will be transmitted in the few feedings that remain.

The second study, conducted in Blantyre, Malawi, was led by Taha E. Taha, of The Johns Hopkins University and Newton Kumwenda, of the University of Malawi College of Medicine. Among the study’s other authors were Dr. Michael Thigpen, of the CDC, and Dr. Mofenson. In a study of 3,016 infants who did not have HIV at birth, the researchers compared two extended regimens of nevirapine (NVP) to the country’s standard treatment: a single dose of NVP given to the mother during labor and to the infant at birth, with daily doses of zidovudine (ZDV) given to the infant during the first week of life.

The infants were assigned at random to one of three groups. The control group received the standard treatment. The next group (the extended NVP group) received the standard treatment plus NVP from day 8 through the 14th week of life. The final group (the extended NVP+ZDV group) received the standard treatment plus NVP and ZDV from day 8 through 14 weeks.

When they were 9 months old, 10.6 percent of infants in the standard treatment group had acquired HIV. By comparison, 5.2 percent in the extended NVP group were infected and 6.4 percent in the extended NVP+ZDV group were infected, corresponding to a 51 percent and 40 percent decrease in HIV infection, respectively. The difference in HIV infection between the two extended treatment groups was not statistically significant.

Infants in the NVP+ZDV group were more likely than infants in the other groups to experience neutropenia, a deficiency of a certain type of an infection-fighting cell. People with neutropenia may be more susceptible to infection.

The study authors concluded that providing anti-HIV drugs to breastfeeding infants is a practical and effective way to reduce HIV infection. They noted that additional studies are needed to determine whether it was safe to provide anti-HIV drugs to infants for the duration of breastfeeding.

Dr. Mofenson said that one NIH-supported study, now in progress, was investigating whether anti HIV drugs could be safely given to breastfeeding infants for the first six months of life. Another NIH effort, now in the planning phase, will compare the effectiveness of infant nevirapine given to breastfeeding infants for the entire duration of breastfeeding, to the effectiveness of providing combination anti-HIV therapy to breastfeeding mothers.

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The NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit the Institute’s Web site at nichd.nih/.

The National Institutes of Health (NIH) – The Nation’s Medical Research Agency – includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit nih/.

Source: Robert Bock or Marianne Glass Miller

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Sanofi-Aventis Response To Lancet Article On Acomplia (Rimonabant)

Below is a response from Sanofi-Aventis regarding an article that appeared in The Lancet about Acomplia (Rimonabant)??

“The meta-analyses published today in the Lancet and BMJ reflect the data previously published, and do not introduce any new information that doctors, sanofi-aventis and regulatory bodies have not already considered and acted upon. The articles summarise the recognised benefits of Acomplia on weight and multiple risk factors, including glycaemic control in those with diabetes.

The authors also report the well established side effect profile, including the psychiatric events that are already appreciated by clinicians who prescribe the product. They highlight that it is important to understand that patients who have been depressed are at risk from further episodes, and should therefore not be prescribed the product.

Since the launch of Acomplia, sanofi-aventis has worked closely to monitor safety, and in conjunction with clinicians and regulatory agencies has actively sought to ensure that treatment is prescribed to the right patient – those who need to reduce their weight as a health priority – whilst minimising use in the wrong patient, in particular excluding those who currently are or who have in the past been depressed.

We are delighted with the way that UK clinicians adopted this strategy into their practice when this recommendation was introduced by the EMEA in July 2007.”

– The Lancet article
– en.sanofi-aventis
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Novel Three-Dimensional Imaging Technique Used By Researchers

FINDINGS: Using an innovative three-dimensional imaging technique, a team of UCLA researchers have tracked how Alzheimer’s disease spreads through the hippocampus — the area of the brain linked with memory — in a pattern consistent with the known trajectory of neurofibrilliary tangle dissemination, an accumulation of diseased proteins in the brain cells. They found that three areas within the hippocampus of Alzheimer’s patients show more atrophy compared with those in patients having amnestic mild cognitive impairment (MCI), a recently defined condition characterized by memory decline but that leaves other daily living activities unimpaired, and which immediately precedes Alzheimer’s.

IMPACT: The technique is significant because it makes it possible to track the progression of Alzheimer’s disease in live patients. This will be crucial in evaluating the effectiveness of drugs that fight Alzheimer’s when they become available for clinical trials.

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AUTHORS: Liana G. Apostolova, Rebecca A. Dutton, Kiralee M. Hayashi, Arthur W. Toga, Jeffrey L. Cummings and Paul M. Thompson, all of the David Geffen School of Medicine at UCLA, and Ivo D. Dinov of the UCLA Department of Statistics.

JOURNAL: Now available online at the Web site of Brain magazine, brain.oxfordjournals/cgi/reprint/awl274v1

FUNDERS: The National Institute of Aging, the American Federation for Aging Research, the National Institute for Biomedical Imaging and Bioengineering, the National Library of Medicine, the National Center for Research Resources, the National Institute for Mental Health, the National Institutes of Health, the National Science Foundation, the American Federation for Aging Research, the John A. Hartford Foundation, Atlantic Philanthropies, the Starr Foundation and an anonymous donor.

Contact: Enrique Rivero

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Hertfordshire group to adopt a new approach to weight loss

A new group which will help women who are seriously overweight to lose weight and keep it off run by the University of Hertfordshire will start in Stevenage in January.

The group, which has been formed by Professor Julia Buckroyd, the University’s Professor of Counselling, and will run for 12 months, and invites women who have serious weight problems, are over 18 and are not involved in any other treatment for weight loss to attend.

Professor Buckroyd, who has proved in recent research that therapy has a role in enabling some women to lose weight and keep it off, believes that eating behaviour is determined in part by emotional states and that therefore presenting women with just a diet will not work.

She commented: “Our research has shown that some of those at risk of serious obesity-related diseases continue to eat chocolate bars so purely putting them on a diet is not an effective treatment. In fact, there is a general despair about the possibility of losing weight through dieting.”

Professor Buckroyd believes that a complete change of lifestyle which leads to new eating behaviour is needed if weight loss is to be achieved and maintained.

She commented: “There needs to be an inner change and our group will help these women to address emotional issues which lead to over-eating as well as focusing on their eating behaviour and activity levels so that they can begin to manage them effectively.”

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Feet First? Old Mitochondria Might Be Responsible For Neuropathy In The Extremities

The burning, tingling pain of neuropathy may affect feet and hands before other body parts because the powerhouses of nerve cells that supply the extremities age and become dysfunctional as they complete the long journey to these areas, Johns Hopkins scientists suggest in a new study. The finding may eventually lead to new ways to fight neuropathy, a condition that often accompanies other diseases including HIV/AIDS, diabetes and circulatory disorders.

Neuropathies tend to hit the feet first, then travel up the legs. As they reach the knees, they often start affecting the hands. This painful condition tends to affect people who are older or taller more often than younger, shorter people. Though these patterns are typical of almost all cases of neuropathy, scientists have been stumped to explain why, says study leader Ahmet Hoke, M.D., Ph.D., a professor of neurology and neuroscience at the Johns Hopkins University School of Medicine.

He and his colleagues suspected that the reason might lie within mitochondria, the parts of cells that generate energy. While mitochondria for most cells in the body have a relatively quick turnover replacing themselves every month or so those in nerve cells often live much longer to accommodate the sometimes long journey from where a cell starts growing to where it ends. The nerve cells that supply the feet are about 3 to 4 feet long in a person of average height, Hoke explains. Consequently, the mitochondria in these nerve cells take about two to three years to travel from where the nerve originates near the spine to where it ends in the foot.

To investigate whether the aging process during this travel might affect mitochondria and lead to neuropathy, Hoke and his colleagues examined nerve samples taken during autopsies from 11 people who had HIV-associated neuropathy, 13 who had HIV but no neuropathy, and 11 HIV-negative people who had no signs of neuropathy at their deaths. The researchers took two matched samples from each person one from where the nerves originated near the spine and one from where the nerves ended near the foot.

They then examined the DNA from mitochondria in each nerve sample. Mitochondria have their own DNA that’s separate from the DNA in a cell’s nucleus.

The researchers report in the January Annals of Neurology that in patients with neuropathy, DNA from mitochondria in the nerve endings at the ankle had about a 30-fold increase in a type of mutation that deleted a piece of this DNA compared to mitochondrial DNA from near the spine. The difference in the same deletion mutation between the matched samples in people without neuropathy was about threefold.

Since mitochondria quit working upon a person’s death, the scientists looked to a monkey model of HIV neuropathy to see whether these deficits affected mitochondrial function. Tests showed that the mitochondria from the ankles of these animals didn’t function as well as those from near their spines, generating less energy and producing faulty proteins and damaging free radicals.

Hoke explains that as mitochondria make the trek from near the spine to the feet, their DNA accumulates mutations with age. These older mitochondria might be more vulnerable to the assaults that come with disease than younger mitochondria near the spine, leading older mitochondria to become dysfunctional first. The finding also explains why people who are older or taller are more susceptible to neuropathies, Hoke says.

“Our mitochondria age as we age, and they have even longer to travel in tall people,” he says. “In people who are older or taller, these mitochondria in the longest nerves are in even worse shape by the time they reach the feet.”

Hoke notes that if this discovery is confirmed for other types of neuropathy, it could lead to mitochondria-specific ways to treat this condition. For example, he says, doctors may eventually be able to give patients drugs that improve the function of older mitochondria, in turn improving the function of nerve cells and relieving pain.

Source: Johns Hopkins Medicine Continue reading

Firms may have to assess mental health in Japan

The Japanese Health, Labor and Welfare Ministry is considering revising the Industrial Safety and Health Law to require companies to assess the mental health of their employees in a bid to urge companies to be sensitive to mental health problems, sources said.

The ministry intends to draft the bill by summer and submit it during the next ordinary Diet session.

According to the sources, under the revision, the ministry would like managers at workplaces and company doctors to know the condition of their employees’ mental health as a result of the diagnoses.

The Japanese government has provided only guidelines on worker mental health. With about 8,000 suicides per year by employees across the country, the ministry decided to launch efforts to address mental health problems.

The current law stipulates that employers should be considerate of employees’ health conditions.

The ministry intends to require employers to assess employees’ mental and physical stress and take steps to address it.

Under the current law, companies are obliged to provide physical checkups for employees and hear opinions from company doctors and deal with the situation appropriately. But in many cases employees feel it is difficult to consult with doctors about mental health during companies’ medical examinations.

In the process of drafting the bill, the ministry therefore intends to make it easier for employees to receive treatment from medical specialists when they feel mentally stressed. If an employee shows his or her company a medical assessment by a psychiatrist outside the company, for example, the company would be required to take proper measures for the employee.

The government will not likely impose penalties on companies in violation of the revised law. But the ministry believes the revision could be effective in urging companies to address mental health problems of employees. This would be particularly so if employees suffering from mental diseases were able to sue employers for negligence under the revised law.

There remain difficult problems such as how to treat different levels of stress and how to distinguish stress caused by factors at home from that caused by work. The ministry has set up a 10-member panel comprised of experts, including doctors, to discuss the problems.

In August 2000, the then Labor Ministry, in its guidelines for worker mental health, asked companies to approve requests for mental health consultations from employees and improve working conditions.

But the number of suicides for workers has remained at 8,000 in recent years and hit 8,215 in 2002.

Yomiuri Shimbun

Source: yomiuri.jp/newse/20040504wo02.htm Continue reading